| Abstract Scope |
Despite the notable advancements made over the past decade in achieving carbon-carbon bonds by transition metal-catalyzed cross-coupling processes, metal-free cross-coupling reactions for hydroacylation of aromatic alkynes via Csp3-H functionalization are still rare and highly desired. Here we report a metal-free reliable approach for the synthesis of α, β-unsaturated ketones (chalcones) via Csp3-H functionalization using MeCN:H2O as green solvent, Eosin Y as organic photocatalyst and ambient air as oxidant. More significantly, this strategy can effectively transform a variety of methyl arenes and aromatic alkynes into the desired product. With high atom efficiency, use of green solvents, metal-free, environment friendliness, and visible light as a renewable energy source, this method is compatible with biologically active molecules. |