| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Sensitivity Analyses of Biomechanical Systems to Estimated Properties of Biological Materials |
| Author(s) |
Douglas Cook |
| On-Site Speaker (Planned) |
Douglas Cook |
| Abstract Scope |
Mechanical modeling of biological systems at tissue, cellular, and sub-cellular level requires numeric values for numerous mechanical properties. These mechanical properties are often poorly understood, and rough estimates often must be used when empirical data is not available. Sensitivity analyses play a critical role in assessing the influence of these material property estimations/assumptions on simulation results. The most common way to obtain sensitivity values is via numerical differentiation scheme where each material property is independently varied to asses its influence on the model response. When N material properties are present, this approach requires N+1 simulations to obtain N material sensitivities of the system. When models are large and/or complex, sensitivity analyses can be costly and time-consuming to perform. This talk will address the importance of providing uncertainty ranges on reported biological materials and of using these uncertainty ranges in the process of performing follow-on analyses. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Composites, Biomaterials, |