| Abstract Scope |
Most nanomedicines use nanostructures as carrier for drugs, making their therapeutic effectiveness dependent on the ability to deliver the drug to the interior of cells (endocytosis). Nano Radioisotopes do NOT require endocytosis, since approaching the cell from the outside (targeting or retention) can be sufficient to kill the cell (i.e. induce apoptosis). In this case, the therapeutic load is radiating energy with sufficient penetration into nearby cells. Radiation methods for the creation of nanostructures also have various advantages over chemical ones. First, the reductive potential induced by radiation is essential instantaneous and uniform throughout the precursor solutions. Finally, the reducing agent is radiation, ameliorating potential contamination issues. Most radioactive nanostructures (non-prompt) are produced by activating precursor elements and then performing radiochemical procedures to make nanostructured forms. Prompt Nano-Radioisotopes make radioactive isotopes in nano form ready to use, reducing the need for facilities to manipulate radiochemicals or radiopharmaceuticals. |