| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biodegradable Materials for Medical Applications II
|
| Presentation Title |
3D-printed Nanocomposites for Bone Repair |
| Author(s) |
Chaoxing Zhang, Catherine Seo, Changlu Xu, Jiajia Lin, Edgar Villafana, Hector Jimenez, Huinan Liu |
| On-Site Speaker (Planned) |
Catherine Seo |
| Abstract Scope |
Biodegradable polyesters such as polycaprolactone (PCL) have been actively studied as tissue engineering scaffolds for decades. The composite scaffolds that consist of polyesters and nano-ceramic phases such as hydroxyapatite (HA), have shown improved mechanical strength and bioactivity. However, infections and unwanted inflammation still occur. Incorporation of nano-sized magnesium oxide (MgO) as an additional phase to PCL/HA can induce antibacterial properties and further improve bioactivity. In this study, PCL-based nanocomposite scaffolds with 0-20 wt.% of HA and 0-1 wt.% MgO were 3D-printed and characterized. To evaluate the cytocompatibility of each scaffold in vitro, a direct cell culture study with bone marrow-derived stem cells (BMSCs) was completed and analyzed. Two triphasic nanocomposites, PCL with 9 wt.% HA and 1 wt.% MgO and PCL with 19 wt.% HA and 1 wt.% MgO showed the best cell adhesion and proliferation, offering promising results for serving as 3D scaffolds for bone regeneration. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |