| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
|
| Presentation Title |
Dynamic Vessel-on-a-chip Model: Bringing Bio-relevance to In Vitro Evaluation of Quantum Dots |
| Author(s) |
Hagar I. Labouta |
| On-Site Speaker (Planned) |
Hagar I. Labouta |
| Abstract Scope |
Microfluidics, manipulation of fluids at the sub-millimetre scale, has given rise to platforms for controlled synthesis of nanomaterials as well as to biomimetic systems called organ-on-a-chip to evaluate nanoparticles under conditions mimicking in vivo scenarios. My talk will focus on our research on synthesizing nanoparticles under controlled flow conditions and examining their interaction with cells exposed to shear stress due to flow. We have developed a vessel-on-a-chip model using vascular endothelial cells (HUVEC) subjected to shear stress within the physiological range, 1 dyne/cm2. Using this model, we examined the effect of wall shear stress on the interaction of quantum dots with the endothelium in regards to cell viability, cell internalization of quantum dots, as well as their effect on the cell transcriptome using microarray analysis. The results of this work will direct future studies towards the use of in vitro approaches for improving in vitro-in vivo correlation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Biomaterials, |