| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Advances in Dielectric Materials and Electronic Devices
|
| Presentation Title |
Magnetically Assisted High-specificity Targeted Drug Delivery Using Magnetoelectric Nanorobots |
| Author(s) |
Nandan Murali, Simran Kaur Rainu, Neetu Singh, Soutik Betal |
| On-Site Speaker (Planned) |
Nandan Murali |
| Abstract Scope |
Unique magnetoelectric nanorobots (MENR) were fabricated using Pechini method for application as drug carrier. MENRs comprise a 30 nm single crystalline magnetostrictive CoFe2O4 core coated with single crystalline BaTiO3 piezo-electric layer. MENRs have the capability of generating switchable electric dipoles on the surface when exposed to bipolar magnetic field. Experiments were performed to analyze the magnetically assisted drug loading and unloading capability of MENRs. The MENRs were further coated with glycerol monooleate (GMO) using EDC chemistry. Extensive analysis using UV-VIS spectrophotometer reveals the high efficiency Doxorubicin drugs loading on the surface of GMO coated MENRs when subjected to 100 Oe dc magnetic field for 20 seconds. Targeted, and on-demand drug release by MENRs were also recorded by subjecting GMO/MENR to -100 Oe dc magnetic fields for 60 seconds. Further, the biocompatibility of MENRs was confirmed by cytotoxicity test performed using MTT assays with human osteosarcoma cell line for 24 hours. |