| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Real Time Imaging
|
| Presentation Title |
G-2: Enhancement of Ultrasound Imaging via Ultrasonic Sheared Nanobubbles |
| Author(s) |
Tara Menon Pattilachan, Pedram Sotoudeh Bagha, Mehdi Razavi |
| On-Site Speaker (Planned) |
Tara Menon Pattilachan |
| Abstract Scope |
Osteoporosis presents a substantial challenge with limited effective therapies. We propose a two-fold solution employing ultrasonic-sheared nanobubbles (NB), a novel fabrication method integrating shearing with ultrasonication, as enhanced contrast agents in ultrasound imaging and siRNA gene therapy vehicles. Experiments were conducted by injecting ultrasonic-sheared NB and control NB into a phantom vessel at various time points post-Low Intensity Pulsed Ultrasound (LIPUS) stimulation. Images were captured by Vevo 3100 US scanner. Grayscale values were quantified via ImageJ across a uniform region of interest. Ultrasonic-sheared NB demonstrated improved performance in US imaging, reaching peak grayscale intensity values of 60.624, 30 minutes post-LIPUS stimulation, compared to 41.479 at immediate release and 60.283 at 60 minutes. In comparison, control NB only achieved a maximum of 36.71 at 60 minutes. Ultrasonic-sheared NB exhibited consistency in results, contrasting with variable control results, highlighting superior US imaging capabilities. Future work will target ultrasound-mediated NB delivery in bone. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Process Technology |