| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
BioNano Interfaces and Engineering Applications
|
| Presentation Title |
Zinc Functionalized Polydopamine-curcumin Coated 3D Printed Calcium Phosphate Scaffolds for Enhanced Osteogenesis, and in Vitro Chemoprevention |
| Author(s) |
Arjak Bhattacharjee, Susmita Bose |
| On-Site Speaker (Planned) |
Arjak Bhattacharjee |
| Abstract Scope |
Osteosarcoma is the predominating bone malignancy which is the third most common cancer among pediatric patients and young adults. Since antiquity, curcumin, from turmeric are utilized in traditional Indian medicine (Ayurveda) to treat bone fractures and related disorders. The current work aims to utilize Zn functionalized polydopamine coating on 3D printed porous tricalcium phosphate (TCP) scaffolds for osteosarcoma inhibition. The binder jetting method was used to fabricate TCP scaffolds with interconnected porosity. Zn functionalized polydopamine coating over the scaffold surface was developed by controlled polymerization of dopamine in presence of zinc chloride. Zn and curcumin together help in osteoblast growth, proliferation, and increases the cell viability to ~ 1.5 times as compared to control. In addition, the presence of curcumin shows ~ 2 folds decrease in osteosarcoma cell viability after day 11. This presentation will discuss the fabrication of Zn functionalized polydopamine-curcumin-coated scaffolds and their osteogenic, chemo-preventive potential. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Additive Manufacturing, Biomaterials, Ceramics |