| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Biomechanical Behaviors of Gingival-derived Mesenchymal Stem Cells (GMSCs) Treated Arthritis Mice Tibia |
| Author(s) |
Yuxiao Zhou, Junlong Dang, Ye Chen, Song Guo Zheng, Jing Du |
| On-Site Speaker (Planned) |
Yuxiao Zhou |
| Abstract Scope |
Rheumatoid arthritis (RA) is a symmetric polyarticular arthritis that primarily affects the small diarthrodial joints of body and causes bone erosion in small and large joints, including knees and shoulders. Only about half of RA patients respond to current treatment methods, and none of these methods are curable. In this study, the effects of a human gingiva derived mesenchymal stem cells (GMSCs) on collagen induced arthritis (CIA) mice are examined by assessing the biomechanical behaviors. GMSCs were IV injected into CIA mice, whereas human dermal fibroblasts were employed as a negative control. The animals were sacrificed with the tibia collected and embedded. Compression test was performed on the tibial plateau quasi-statically in a mechanical tester coupled with micro-CT. 3D full-field strain inside tibial plateaus was mapped by digital volume correlation of micro-CT images collected at no-load and loaded conditions. The results demonstrate that the GMSCs-treated group exhibited much lower strain as compared with the negative control group, which indicates the improvement of load-bearing functions of tibia plateaus after GMSCs treatment. In conclusion, infusion of GMSCs shows therapeutic effects on CIA mice by alleviating bone erosion. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |