| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Novel Architectured Materials for Treating Heart Disease |
| Author(s) |
David Restrepo, Juan Sebastian Rincon, Hai-Chao Han |
| On-Site Speaker (Planned) |
David Restrepo |
| Abstract Scope |
Myocardial infarction (MI) produces a deterioration of the pump function, leading to heart failure. Currently, Cardiac patches (CPs) are used to strengthen the infarcted wall to improve cardiac function post-MI. However, CPs have two major limitations: (i) CPs can only provide passive support to the scar tissue and no ability to assist heart contraction. (ii) CPs need to be stiff enough to provide sufficient support but cannot be too stiff to limit diastolic filling. It is of clinical interest to design a smart material to fulfill these limitations. In this work, we present a new architecture material that generates shrinkage (contraction) when subject to tension from surrounding heart wall tissue contraction, so it can assist heart contraction (enhance systolic function) and conform better to the natural heart movements and mechanical properties. Specifically, we will discuss the design, mechanical features, and limitations of such material. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |