| Abstract Scope |
Zinc (Zn) has recently emerged as a novel biodegradable metal thanks to its important physiological roles and promising degradation behavior. However, cytocompatibility of pure Zn is still suboptimal, in part, due to the excessive Zn ions released during degradation. To enhance the biocompatibility of Zn metallics, bioactive coatings including zinc phosphate (ZnP), zinc oxide (ZnO), and zinc hydroxide (Zn(OH)2) were prepared on pure Zn to enhance its biocompatibility. Data shows that ZnP, not ZnO or Zn(OH)2, significantly enhances its biocompatibility. The surface morphology and controlled Zn ion release were shown to be pivotal for the cytocompatibility and antibacterial performance of ZnP coated materials. The decreased Zn ion release and surface morphology significantly enhanced the pre-osteoblast and vascular cell adhesion, viability, and proliferation. Moreover, the micro- and nano-structures of ZnP formed on Zn surface significantly reduced the bacterial adhesion and growth. |