| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
|
| Presentation Title |
Facile Synthesis of Novel Quaternary Zn-Cu-In-S/ZnS QDs- mTHPP Porphyrin Conjugate and Its Photodynamic Therapy of Cancer and Antibacterial Activities |
| Author(s) |
Samuel Oluwatobi Oluwafemi |
| On-Site Speaker (Planned) |
Samuel Oluwatobi Oluwafemi |
| Abstract Scope |
Photodynamic therapy (PDT) is a non-invasive treatment modality that uses photosensitizing drugs (PS) to generate reactive oxygen species for the destruction of abnormally growing cells or microorganisms. Porphyrins are the most widely used PS in PDT however, their clinical application is limited by poor water solubility, which often results in aggregation and their low quantum yield of ROS generation after light absorption in the near infra-red region (NIR. To overcome these limitations and improve PDT efficacy, we herein report the conjugation of Zn-Cu-In-S/ZnS (ZCIS/ZnS) quantum dots (QDs) to 5,10,15,20 meso (4-hydroxyphenyl) porphyrin (mTHPP) and evaluated its PDT efficiency against murine metastatic melanoma (B16 F10 Nex 2) cell line and its antibacterial potency against Escherichia coli (ATCC 25922). The results of this study show that the as-synthesized ZCIS/ZnS – mTHPP conjugate is a suitable and promising class of material for dual anti-cancer and antimicrobial PDT. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Other |