| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials
|
| Presentation Title |
Regioselective self-assembly of biomolecules guided by moiré-patterned 2D homo/heterostructures |
| Author(s) |
Daiyue Wei, Yi Yang, Ossie Douglas, Zhewen Yin, Muhammad Shahbaz Rafique, Keegan Suero, Sofia Isabel Morales Ferreira, Nathan D. Gallant, Michael Cai Wang |
| On-Site Speaker (Planned) |
Daiyue Wei |
| Abstract Scope |
Recent observations of regioselective water condensation, metallic nanoparticle nucleation/growth, and other heterogeneous surface/interface effects on specific periodic moiré domains of van der Waals 2D layered materials suggest novel, yet complex effects of lattice mismatch and atomic reconstruction. Here, we extend exploration of such emergent phenomena to the adsorption and separation of biomolecules. Guided by the moiré-induced interfacial charge redistribution and concomitant surface potential patterns, 2D homo/heterostructures show regioselective, domain-dependent adsorption of monodisperse proteins and isolation of protein mixtures. This demonstrates the potential of moiré-engineered surfaces and interfaces to serve as tunable templates for biomolecular self-assembly and self-sorting, which may enable novel future applications in single-molecule biosensing and enantioselective purification for biopharmaceutical manufacturing. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Thin Films and Interfaces |