| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques |
| Author(s) |
Bernd Gludovatz, Mihee Shin, Russel T. Turner, Urszula Iwaniec, Jamie J. Kruzic |
| On-Site Speaker (Planned) |
Bernd Gludovatz |
| Abstract Scope |
Chronic heavy alcohol consumption may influence the skeleton by suppressing intracortical bone remodeling thereby impacting the quality and mechanical properties of bone. Here, we present our work on the effects of chronic heavy alcohol consumption on the material properties of various groups of male rhesus macaques that were induced to drink alcohol. Dynamic mechanical analysis, nano-indentation, microhardness, compression, and fracture resistance curve testing was conducted on the distal tibia diaphysis of 2–5 monkeys per test group and compositional analyses performed using Fourier-transform infrared spectroscopy. While most tests show only minor differences between the alcohol groups and control samples, a statistically significant decrease in crack growth toughness and increase in storage modulus and loss factor with alcohol consumption were found. Our results indicate that heavy alcohol consumption may have only a minor influence on the material properties and the composition of cortical bone in young adult male rhesus macaques. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Characterization |