| Abstract Scope |
The antiproliferative pharmaceutical rapamycin was grown as coatings on glass surfaces using matrix assisted pulsed laser evaporation. The matrix assisted pulsed laser evaporation procedure allows for precise control of coating roughness; additionally, the matrix assisted pulsed laser evaporation coating technique that does not heat the biological molecules. The proliferation and vitality of L929 murine fibroblast cells were studied using Pico Green and Alamar Blue studies, respectively. In comparison to the borosilicate glass control material, the cells on the rapamycin coatings demonstrated a 53.7 percent proliferation rate (p=0.0120) and a 70.6 percent viability rate (p=0.0097), respectively [1]. This study indicates that the the cell viability and proliferation rates were successfully decreased by the rapamycin coatings.
[1] Cristescu R, Negut I, Visan AI, Nguyen AK, Sachan A, Goering PL, Chrisey DB, Narayan RJ. Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity. International Journal of Bioprinting. 2020;6(1). doi: 10.18063/ijb.v6i1.188 |