| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Functional and Structural Thin Films and Coatings
|
| Presentation Title |
Biomimetic Calcium-deficient Hydroxyapatite Coating on Activated Carbon Fiber Cloth: A Dual Drug Delivery System |
| Author(s) |
Sylvie Bonnamy |
| On-Site Speaker (Planned) |
Sylvie Bonnamy |
| Abstract Scope |
A biomaterial able to control a drug release is highly desired for bone regeneration. Calcium-deficient hydroxyapatite (CDA) coatings deposited on activated carbon fiber cloth are produced by sono-electrodeposition process. The adsorption and desorption properties of each component and of the composite (CDA coating on carbon substrate) are studied, with the objective to develop a dual release biomaterial. For that, the adsorption and desorption of two drugs was investigated. One has a broad spectrum antibiotic (tetracycline), the other one is a nonsteroidal anti-inflammatory (aspirin). The results showed that drug adsorption and release depend on the adsorbent and the drug polarity/hydrophilicity. For the composite, two distinct modes of release are observed. In vitro biological tests showed an increase of the human osteoblasts viability on biomaterial with adequate drug adsorption. For in vivo tests, carbon/ apatite/aspirin materials implanted in bone defect performed on femur of rats showed an acceleration of bone regeneration. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Surface Modification and Coatings, Characterization |