| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Controlled Drug Diffusion Kinetics in HEMA-backbone Hydrogels for Ocular Disease Treatment |
| Author(s) |
Parker M. Toews, Jeff Bates |
| On-Site Speaker (Planned) |
Parker M. Toews |
| Abstract Scope |
Drug diffusion kinetics were studied as a function of hydrogel cross-linking density and porosity. By varying concentrations of cross-linker, triethylene glycol dimethacrylate (TEGDMA), in a 2-hydroxyethyl methacrylate (HEMA) backbone hydrogel, it was demonstrated how the kinetics could be controlled to allow for controlled drug delivery of Timolol, a glaucoma medication. Cross-linking density was determined using both mathematical models and experimental techniques, such as FTIR and UV-Vis. Using the Beer-Lambert Law, the partition coefficient could be determined. Porosity was studied by using SEM to evaluate the surface of the hydrogel. Mechanical techniques, like DMA, were used to supplement the inferences developed from spectroscopy. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Characterization |