| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Curcumin and Epigallocatechin Gallate Enhance Osteogenic and Antibacterial Properties of HA-coated Titanium Implant |
| Author(s) |
Priya Kushram, Susmita Bose |
| On-Site Speaker (Planned) |
Priya Kushram |
| Abstract Scope |
Orthopedic device-related infection, significantly caused by staphylococcus aureus, remains a major complication in patients post-implantation surgery. Further, using synthetic drugs to treat infections has led to multidrug resistance and other toxicity concerns. In this work, we have developed a safer approach by using curcumin and epigallocatechin gallate (EGCG), the natural and bioactive compounds from turmeric and green tea. These drugs have been known for their excellent antibacterial and bone-forming ability. We aim to fabricate hydroxyapatite (HA) coated titanium implants loaded with both compounds to heal bone defects while preventing infection. The results indicate that the controlled release of combined drugs showed significant antibacterial efficacy against staphylococcus aureus by 94 % and enhanced osteoblast cellular viability by 3-fold compared to the untreated substrate. In essence, this study investigates the effect of a bioactive HA-coated implant loaded with natural compounds that could serve as a promising strategy for bone tissue engineering. |