| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Insights to Enhance Toughness of Human Bone through Nanoscale Deformation and Fracture Analysis |
| Author(s) |
John A. Howarter, Thomas Siegmund, Elizabeth Montagnino, Glynn Gallaway |
| On-Site Speaker (Planned) |
John A. Howarter |
| Abstract Scope |
Fracture and disease models for the human bone has traditionally been based on accessible animal studies, which provide limited information to the human bone. We aim to further the understanding of how organic-mineral phase interactions at the nanoscale as well as the microstructure surrounding the eventual crack path can together predict susceptibility to fracture in human bone. Recent work on cortical human femur has led to new insights on mechanical behavior of bone and how we can best model the fracture zone. Similarly, analysis with small angle x-ray scattering and magnetic resonance imaging were used to map nanoscale structural and chemical changes under a range of ex-vivo treatment conditions. The disruption or enhancement at the collagen and mineral interface, as well has hydration levels, were found to be predictive of fracture behavior.
This work is supported by NSF Award 1952993. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Mechanical Properties |