| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
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| Presentation Title |
A Bilayered GelMA/PEGDA-based Nerve Conduit with Supportive Cells for Peripheral Nerve Regeneration |
| Author(s) |
Jingyi Liu, Yun Yin |
| On-Site Speaker (Planned) |
Jingyi Liu |
| Abstract Scope |
Rupture of a nerve is a debilitating injury and is usually presented with poor quality of life in patients. The gold standard of repair is the use of an autologous graft. Autografts however lead to inadequate functional recovery and involve risks due to secondary surgery at the donor site. Here we report a novel 3D-printed bilayered gelatin methacrylated/Poly (ethylene glycol) diacrylate (GelMA/PEGDA)-based conduit combined with bone marrow stem cells (BMSCs). This study examined the physical, mechanical and biological properties of the conduits for neural reconstruction applications. In vitro characterization demonstrated that the conduit possessed strong mechanical strength with compressive modulus of 1.61N/mm. In vitro cell culture showed that PC12 cells attachment, spreading and proliferation on the GelMA/PEGDA seeded with BMSCs were great. Collectively, this study suggests that GelMA/PEGDA-based bilayered nerve conduit seeded with BMSC shoes great promise for improving the current state of art in peripheral nerve repair strategies. |
| Proceedings Inclusion? |
Planned: |