| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Structure-Property Relationships in Molecular Crystal Deformation
|
| Presentation Title |
Elucidating Tabletability of Pharmaceutical Solids based on Plasticity Quantified by Nanoindentation |
| Author(s) |
Changquan Sun |
| On-Site Speaker (Planned) |
Changquan Sun |
| Abstract Scope |
The plasticity of solid materials plays critical roles in their ability to form tablets through the process of compression. Among available techniques for quantifying material plasticity, nanoindentation is gaining attraction because of its ability to accurately quantify plasticity while only requiring the use of very little material. Hence, it can be adopted early in drug development to guide tablet formulation design. In this talk, the use of nanoindentation to quantify material plasticity to understand compaction behaviors of crystalline materials and amorphous solids will be discussed with examples. For example, plasticity informs the understanding of diverse tableting behaviors of crystals based on the bonding area – bonding strength (BABS) interplay model. The dependence of the plasticity of amorphous solid dispersions as a function of water content and drug-polymer composition is delineated from nanoindentation data in model systems and their diverse tableting behaviors are explained. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Powder Materials, Nanotechnology, Characterization |