| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Aerosol Jet-Printed MEAs for 3D Electrophysiological Mapping in Cardiac Disease
Modeling |
| Author(s) |
Methu Dev Nath, Mabel Bartlett, Mengdi He, Tzahi Cohen-Karni, Rahul Panat |
| On-Site Speaker (Planned) |
Methu Dev Nath |
| Abstract Scope |
Cardiovascular diseases (CVD), the leading global cause of death, underscore the critical need for advanced cardiac disease tracking to enhance therapeutic interventions development. Three-dimensional (3D) cardiac organoids, which mimic the human heart’s electrophysiology, are crucial for studying CVD progression and evaluating new therapeutics. Traditional 2D microelectrode arrays (MEAs) inadequately capture the complex electrophysiological interactions within these organoids necessary for CVD progression investigation. We introduce a novel 3D MEA for cardiac organoid investigation. Our arrays, fabricated using Aerosol Jet printing of Ag interconnects and Au pillars at a 250 µm pitch with heights between 150-300 µm, are passivated with Parylene-C. Electrode tips are exposed by Plasma Focused Ion Beam (PFIB) and surface-modified with Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) to reduce impedance. This approach enables chronic monitoring of dynamic electrophysiological processes across different cell types and tissue layers, thereby enhancing our understanding of CVD mechanisms and potentially streamlining the development of effective treatments. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Additive Manufacturing, Biomaterials, Nanotechnology |