| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials
|
| Presentation Title |
Facile Synthesis of Aloe-Gold Nanoclusters and Their Molecular Binding, Antibacterial and Cytotoxicity Profiling |
| Author(s) |
Thabang Calvin Lebepe, Oluwatobi Samuel Oluwafemi |
| On-Site Speaker (Planned) |
Thabang Calvin Lebepe |
| Abstract Scope |
Gold-nanoclusters (AuNCs) usage has increased over the years. However, their applications are limited by toxic and costly chemicals used during synthesis. Hence, this study shows a simple microwave-assisted synthesis of AuNCs using Aloe-africana leaf extract (Aloe-AuNCs) for different biological applications. The optical properties and morphology were investigated by varying various parameters. Their average size was 4.70 ± 1.07 nm, with maximum emission at 560 nm and 2.17 % quantum yield. They showed good molecular binding ability due to the high content of carbonyls with the binding constant of 1.47 × 10−2. They were stable for up to 48h, showed inhibition against S.aureus and E.coli and were biocompatible against THP-1 cell lines. The study demonstrates that these AuNCs can bind with molecules for drug delivery, display antibacterial activity, and exhibit good cell viability. Furthermore, Aloe Africana extracts can serve as a substitute for other aloe species in the synthesis of nanomaterials. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Sustainability |