| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Continuous Monitoring of Biomarkers with Minimally-invasive Wearable Microneedle Patch Sensors |
| Author(s) |
Andreas Stein, Yevedzo Chipangura, Vilma Brandao, Xiaohang Zhi, Sarah Swisher, Philippe Buhlmann, Elizabeth Lusczek, Eric Wise, Greg Beilman |
| On-Site Speaker (Planned) |
Andreas Stein |
| Abstract Scope |
There is a need in emergency medicine for low-cost diagnostic equipment that can continuously monitor biomarkers without requiring trained personnel. We will discuss our approach toward minimally-invasive microneedle sensor arrays that only penetrate the skin deep enough to sample molecular analytes in interstitial fluid (ISF). We have converted acupuncture needles 160 µm in diameter into functioning potassium-ion-selective sensors. This high degree of miniaturization required optimizing the synthesis of mesoporous carbon nanoparticles as solid contacts to ensure stable measurement signals, and developing methods of coating the needles with robust films of these particles and with ionophore-containing polymer membranes. Our microneedle sensors have the same selectivity and sensitivity as bulky, standard laboratory potentiometric sensors in response to electrolyte solutions. The microneedles are assembled into a flexible patch-like device patterned with inkjet-printed thin-film conductive materials, which provides mechanical flexibility and allows rapid design changes. |