| Abstract Scope |
Natural medicinal compounds (NMCs) can treat bone disorders with osteogenic properties. Their inferior bioavailability and optimized efficacy halt their therapeutic applications. Nanoformulations loaded onto bioceramics scaffolds hold clinical significance by enhancing tissue regeneration, enabling efficient delivery, minimizing immune responses, offering safer, and effective therapies. We have encapsulated NMCs, e.g. curcumin, allicin, Gingerol, quercetin, and vitamin D3, in solid lipid nanoparticles to achieve a 2-4-fold increase in osteoblasts while enhancing cytotoxicity against bone cancer cells. Carvacrol-encapsulated nanocarriers reduce Staphylococcus aureus colonies by ~80-90%, while Gingerol nanocarriers show lowered osteosarcoma cells by 2-3-fold compared to the control. Curcumin and carvacrol co-loaded lipid nanoparticles inhibit osteosarcoma and bacterial cells. Polycaprolactone encapsulated resveratrol enhances bone regeneration and cytotoxicity against cancer cells. In Vivo studies using rat and rabbit distal femur models and in vitro results indicate that NMC functionalized nanocarriers in 3D-printed multi-functionalized scaffolds can be used in treating patient-specific bone-defect healing. |