| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Long-term in vivo Cyclic Loading Upregulates the Effects of Osteoporosis Treatment |
| Author(s) |
James Rosenberg, Ursula Eberli, Stephan Zeiter, Vincent Stadelmann, Claire Acevedo |
| On-Site Speaker (Planned) |
James Rosenberg |
| Abstract Scope |
Physical activity is known to stimulate bone cell damage removal and new bone formation. High magnitude cyclic loading from extreme activity on weak osteoporotic bone can induce stress fractures whereas low magnitude cyclic loading from daily activity tends to increase bone resistance to fracture. The most common treatment for osteoporosis, namely bisphosphonate treatment, is inhibiting bone resorption to rebuild bone. In this study, we investigated the effects of weekly in vivo fatigue loading on murine hind limbs and bisphosphonate treatment on bone’s ability to adapt to damage in ovariectomized and control mice. After sacrifice, ex vivo fatigue testing to failure was used to compare bone resistance. We found that in vivo loading combined with osteoporosis treatment was significantly increasing tibial bone formation and fatigue resistance. These results can help in identifying the beneficial and detrimental effects of cyclic loading in osteoporotic bone, as well as future development of strengthening treatments. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |