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Meeting 2025 TMS Annual Meeting & Exhibition
Symposium Advanced Biomaterials for Biomedical Implants
Presentation Title Machine Learning-Driven Magnesium Alloy Design for Biomedical Implants Through Process Optimization
Author(s) Sreenivas Raguraman, Maitreyee Sharma Priyadharshini, Adam Griebel, Paulette Clancy, Timothy Weihs
On-Site Speaker (Planned) Sreenivas Raguraman
Abstract Scope Magnesium alloys present a compelling alternative to conventional orthopedic implant materials due to their biodegradability, biocompatibility, and impressive mechanical characteristics. However, their rapid deterioration challenges practical applications, by compromising mechanical integrity. This study develops a predictive numerical model to identify optimal processing routes for strong and corrosion-resistant Mg alloys. We processed ZX10, a dilute Mg-Zn-Ca-Mn alloy, through over 40 combinations of thermal, mechanical, and thermomechanical techniques, and rapidly quantified the properties via hardness and immersion experiments. This data is integrated into a machine learning framework using Bayesian Optimization to link processing routes to desired properties. Employing a closed-loop paradigm, we experimentally validate our models and refine them based on experimental data, recommending optimal processing routes. This iterative approach achieves the best combination of high hardness and low corrosion rates, fine-tuning the model to accurately predict corrosion and hardness as a function of processing.
Proceedings Inclusion? Planned:
Keywords Biomaterials, Magnesium, Machine Learning

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

A Plasma-3D Print Duo Platform for Reliable Materio-Biological Screening In Vitro
Advancing Dental Implant Technologies: Characterizing Ti-Cu Alloys Using Core/Shell Structures for Enhanced Mechanical Properties and Corrosion Resistance
An Overview of the Microstructural, Physical, Mechanical, and Tribological Performance of Beta-Type titanium Alloys for Total Hip Replacement
Biocompatibility and Biocorrosion Behavior of Resoloy for Absorbable Vascular Implants
Biodegradable Gel Electrolyte for Bioresorbable and Implantable Biomedical Devices
Biofunctionalization of the Ti-25Ta-xNb Alloy System
Biomimetic Collagen-Based 3D Printed Poly (Glycerol Sebacate) Composite Scaffold to Enhance Cartilage Defect Repair
Design of Bio-High Entropy Alloys with Suppressed Elemental Segregation for Laser Powder Bed Fusion Process
Design, Processing, and Evaluation of Ti-Containing High Entropy Alloy for Bioimplants Applications
Development and Characterization of a Low-Cost High-Entropy Alloy for Potential Application in the Biomedical Field as Bone Fixation Devices
Enhancing IoMT with Biocompatible Triboelectric Nanogenerators for Sustainable Medical Device Powering
Enhancing Structural Efficiency Through Design Tactics for Biomimetic Nested Cylindrical Frameworks
From Corrosion to Mechanics: Evaluating Novel Magnesium Alloys for Biodegradable Wire Applications
Functionally Gradient Nitinol Structure with Pure Titanium Layers and Hydroxyapatite Over-Coating for Orthopedic Implant Applications
High Throughput Exploration of Mo-Ag Alloys for Antibacterial Coatings on Medical Implants
In-Vitro Comparative Study of Composite Coatings for Magnesium-Based Bone Implants
In-Vitro Response to Bioinspired Helically Coiled Electrospun Fibers for Cardiac Patch Application
Influence of Forging Temperature on Microstructure and Texture Evolution and Its Implication on Mechanical, Corrosion, Antibacterial and In Vivo Biocompatibility of Mg-Zr-Sr-Ce Alloy
Influence of Laser Power and Scanning Speed on Performances of LPBF Fe-16Mn-0.7C for Bioabsorbable Stent Applications
Innovative Biodegradable Zn Alloys Produced by Rapid Solidification
Innovative Bone Implants: Drawing Inspiration from Marine Sponges for Next-Gen Solutions
Looking Beneath the Surface: an Ex Vivo Study of Dental Composite Resin Performance in Extracted Human Teeth
Low-Percentage Copper Doping To Optimize The Antimicrobial Properties Of Fluorapatite For Bone Scaffold Applications
Machine Learning-Driven Magnesium Alloy Design for Biomedical Implants Through Process Optimization
Mechanical Testing of Implantable Neuromodulation Components and the Open Source Community
Multifunctional Cobalt and Cerium Co-Doped 58S Bioactive Glass Nanoparticles with Elevated Angiogenic, Antibacterial, and Mechanical Properties
Novel Bio-TWIP Ti and Zr Alloys for Implants: Alloy Design Strategy, Mechanical Properties and Deformation Mechanisms
Novel Surface Treatment of Ti-containing Multiprincipal Element Alloys for Orthopedic Implants
Process Optimization and Biocompatibility of PEEK-HA-Carbon Composites
Production of Tantalum Nitride by Reactive Powder Bed Fusion for Bone Tissue Engineering Applications
Structural Properties of Ti-xNb Alloys for Biomedical Applications
Synthesis and Corrosion Behavior of Nitinol for Biomedical Applications Produced by Mechanical Alloying Method
Tribo-Corrosion Properties of Beta-Type Ti-Nb-Ga Alloys for Antibacterial Implant Applications
Unraveling Fracture Growth in 3D Printed Structures Mimicking Spicules via Computer Tomography (CT) Examination

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