| Abstract Scope |
Assisted reproductive technologies (ART) have transformed reproductive medicine, yet the impact of polymer materials on gamete viability remains poorly understood. This study investigates the influence of various polymer properties on sperm function and viability over time. Initial findings indicate a connection between gamete viability and polymer material selection. Factors such as functional groups, surface charge, morphology, and other polymer characteristics contribute to decreased sperm motility. Recent product substitutions have resulted in increased gamete toxicity. Our multifaceted approach involves exposing gametes to different ART polymers and evaluating viability using the hamster egg penetration test. Additionally, we employ the "sperm racetrack," an innovative microfluidic channel, to assess sperm's linear velocity, swim efficiency, and motility longevity. This investigation aims to identify material properties influencing gamete viability and optimize polymer compositions in ART, thereby enhancing success rates and effectiveness of assisted reproductive techniques for individuals and couples facing fertility challenges. |