| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
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Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
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| Presentation Title |
A Portable Microcontroller Based Aptasensor for In-vitro Amodiaquine Sensing |
| Author(s) |
Pranav Shrotriya, Nianyu Jiang |
| On-Site Speaker (Planned) |
Pranav Shrotriya |
| Abstract Scope |
Monitoring specific binding events between target molecules and biorecognition elements, such as aptamers, within nanochannels, offers an appealing sensing mechanism. Impedance change based sensing requires a potentiostat to provide stability and versatility. To address the need for an alternative to potentiostat, our research group presents a signal processing chip (ADuCM350) based impedance reader. We employed an amodiaquine aptamer-immobilized nanoporous alumina membrane as the sensing platform to evaluate the performance of the impedance reader and a commercial potentiostat. Our results demonstrate comparable KD values of 2 nM and 4 nM from the potentiostat and impedance reader, respectively, for amodiaquine sensing. The impedance reader exhibited a higher LOD (~25 nM) than the potentiostat (~8 nM), which may explain the slightly lower accuracy and resolution observed. Nonetheless, the impedance reader shows promising potential for future point-of-care applications due to its affordability, compact size, and automation advantages |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Thin Films and Interfaces, Biomaterials |