| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Hybrid Nanoparticles Loaded with a Combination of Aloe Vera and Moringa Oleifera Extracts for Improved Modulation of the Expression of Profibrotic and Proinflammatory Markers in Human Hepatic Stellate Cells and Hepatocytes |
| Author(s) |
Gabriela I. Carballo-López, Jhordan Ojeda-González, Kevin D. Martínez-García, Karla E. Cervantes-Luevano, Aldo Moreno-Ulloa, Ana B. Castro-Ceseña |
| On-Site Speaker (Planned) |
Gabriela I. Carballo-López |
| Abstract Scope |
Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease marked by lipid accumulation, with limited effective treatments due to inaccessibility and non-specificity. Poly (lactic-co-glycolic acid)-lecithin nanoparticles (PLGA-HSPC NPs) offer a promising vehicle for targeted drug delivery by improving bioactive compound solubility. We synthesized PLGA-HSPC NPs loaded with Aloe vera and Moringa oleifera phytochemicals to enhance antioxidant and anti-inflammatory delivery in human stellate cells (HHSC-N) and hepatocytes, modulating MASH-related gene expression. This study evaluated the bioactive compounds, their metabolomic profiles, and effects on HHSC-N and hepatocytes, along with the physicochemical properties of the synthesized NPs. Molecular alignment tested structural similarity with hesperetin, an FDA approved TGF-β inhibitor. We identified 84 chemical classes and found that PLGA-HSPC NPs demonstrated better cytocompatibility and gene expression modulation in COL1A1 and TGF-β genes compared to the phytochemical combination alone, suggesting PLGA-HSPC NPs as an excellent delivery vehicle for phytochemical compounds. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Nanotechnology |