About this Abstract |
Meeting |
MS&T24: Materials Science & Technology
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Symposium
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Next Generation Biomaterials
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Presentation Title |
New Generation of Bioceramics With Complex Structure and Chemical Composition Based on Glaserite-Like Phases for Personalized Bone Tissue |
Author(s) |
Pavel Evdokimov, N. Leontyev, V. Bitanova, D. Larionov, A. Murashko, D. Golubchikov, E. Klimashina, Ya Filippov, A. Garshev, I. Scherbakov, V. Dubrov, A. Efimenko, G. Shipunov, O. Kapitanova, I. Veselova, V. Putlayev |
On-Site Speaker (Planned) |
Pavel Evdokimov |
Abstract Scope |
The main scientific problem is the development of physico-chemical and engineering principles of bone tissue reconstruction using tissue-engineered structures based on resorbable highly porous phosphate ceramics with a given complex architecture as a carriers of cells and drugs. Modern approaches to bone defect repair practically do not take into account the moments of complex bone tissue structure and multimodal conjugation with the complex of adjacent tissues. The complex nature and functionality of each organ results in different rates and mechanisms of their regeneration, which can ultimately lead to the dominance of recovery of one type of tissue over the others. In this context, the scaffold design should take into account the complexity of the structure and environment of the reconstructed bone and therefore be a combination of different materials with individual macrostructures, chemical compositions and a range of mechanical properties.
This work was supported by the RSF [projects #22-19-00219, 23-79-10103, 24-29-00396]. The authors acknowledge the partial support from the Lomonosov Moscow State University Development Program. |