| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Nanocomposites VI: Nanoscience and Nanotechnology in Advanced Composites
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| Presentation Title |
Bioresorbable Nano Hydroxyapatite Reinforced Magnesium Alloplastic Bone Substitute for Biomedical Applications: A Study |
| Author(s) |
Somasundaram Prasadh, Vyasaraj Manakari, Gururaj Parande, Srivatsan Tirumalai, Raymond Wong, Manoj Gupta |
| On-Site Speaker (Planned) |
Somasundaram Prasadh |
| Abstract Scope |
Combining the mechanical, biological and corrosion properties of magnesium can enable it to perform as a biocompatible and degradable implant for load-bearing applications. Accordingly, the present study focuses on determining the influence of Hydroxyapatite nanoparticles on mechanical strength, immersion resistance and cytocompatibility properties of magnesium processed by the powder metallurgy technique. In-vitro cytotoxicity and cell proliferation were done using LDH enzyme release assay and MTS assay. The in vitro biocompatibility and cell viability were determined by attachment of a direct cell to the samples. The addition of nano hydroxyapatite to pure magnesium did not alter the cytocompatibility of the composite. With the addition of 0.5 pct. nano hydroxyapatite to magnesium, the MC3T3-E1 cells revealed significant cell growth. Among the samples tested, cell viability data revealed that the 0.5 pct. hydroxyapatite exhibited the lowest cytotoxicity coupled with increased cell viability. The LDH enzyme release assay results revealed the MC3T3-E1 cells cultured in the presence of low and high concentrations of nano hydroxyapatite for 24 hours to support the cytocompatibility of the synthesized composite. No observable toxic effects were evident, which is consistent with the enhanced corrosion resistance of magnesium alloys resulting in better cell attachment and more cell viability. The inclusion of nanosized reinforcements restricted the growth of grains for magnesium while concurrently enhancing both the compression and biological properties. The immersion tests revealed controlled weight loss for the Mg-0.5 vol.% nano hydroxyapatite composite. |
| Proceedings Inclusion? |
Planned: |