| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Small-scale Deformation Mechanisms of Collagen-based Biological Materials: A Systematic Review And Meta-analysis |
| Author(s) |
Lander Manrique, Meisam Asgari, Elizabeth Zimmermann |
| On-Site Speaker (Planned) |
Lander Manrique |
| Abstract Scope |
Collagen fibrils are the basic building block of a large range of tissues from fish scales and tendons to bone. Over the past 20 years, more than 50 studies have explored the nano-scale deformation mechanisms in collagen-based tissues using synchrotron x-ray diffraction based techniques. The tissues studied have varying degrees of mineralization (from non-mineralized tendons to bone) and hierarchies. In this systematic review and meta-analysis, we adhere and synthesize the studies that have assessed deformation at the collagen fibril scale in type I collagen-based tissues through mechanical testing in combination with X-ray diffraction-based techniques. We compare the elastic and plastic deformation mechanisms as a function of mineralization and disease. This work is important because it reveals the breadth of knowledge generated from synchrotron x-ray diffraction studies, it highlights knowledge gaps, and it synthesizes fundamental knowledge about collagen fibril deformation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Mechanical Properties |