| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biodegradable Materials for Medical Applications II
|
| Presentation Title |
Biocompatibility Study of Luminescent Hydroxyapatite |
| Author(s) |
Fabian Martinez, Ekaterina Novitskaya, Manuel Herrera, Karla Juarez-Moreno, Olivia A. Graeve |
| On-Site Speaker (Planned) |
Fabian Martinez |
| Abstract Scope |
We present a biocompatibility study of hydroxyapatite doped with rare-earth elements, including Eu<sup>2+</sup>, Eu<sup>3+</sup>, Ce<sup>3+</sup>, Tb<sup>3+</sup>, and Yb<sup>2+</sup>, and a cathodoluminescence study of the chemical decomposition of the hydroxyapatites in the presence of simulated body fluid. Before assay studies, the hydroxyapatite powders were analyzed by X-ray diffraction and spectral cathodoluminescence, confirming that the dopants are present in the powders in amounts of a few atomic percent and they do not modify the equilibrium phase of hydroxyapatite. For the biocompatibility study, cytotoxicity assay and hemolysis assay were performed. The cytotoxicity assay of murine pre-osteoblast cells and the hemolysis assay demonstrate that the doped hydroxyapatite does not interfere on the proliferation of the cells, and does not induce the destruction of erythrocytes, respectively. Cathodoluminescence shows that the emission of the dopants decreases in a linear manner when they are immersed in simulated body fluid for different periods of time. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |