| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
Magnetoactive Hydrogels to Fabricate Tissue Patterns |
| Author(s) |
Claudia Loebel, Avinava Roy, Zhang Zenghao, Abdon Pena-Francesch |
| On-Site Speaker (Planned) |
Claudia Loebel |
| Abstract Scope |
Abnormal folding of mucosal tissues, such as within the epithelium of the upper respiratory airways is often a consequence of diseases, including chronic injury and fibrosis. Studying the influence of these tissue abnormalities on cellular function is challenging due to the lack of cell culture platforms that can mimic tissue folding in vitro. To address this, we developed bilayer folding systems composed of tough double network and rigid covalent hydrogels to generate tissue-like patterns based on mechanical instabilities. DN hydrogels were further mixed with micromagnetic particles to provide dynamic uni- and bidirectional patterns
Using different pre-strain ratios and hydrogel elastic moduli values generated characteristic static ridges, wrinkles and folds as dictated by mechanical instabilities. Embedding of magnetic microparticles inside the DN pre-gel enabled generation of similar but dynamic and reversible patterns through a fluctuating magnetic field.
Reversible and dynamic patterning holds promise to recapitulate mucosal tissue-dynamics. |