| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
H-4: Electrospun Metal Mediated Cerium Oxide/Silk Nanocomposites for Wound Dressing |
| Author(s) |
Elayaraja Kolanthai, Craig Neal, Yifie Fu, Wesley Matthiesen, Sudipta Seal |
| On-Site Speaker (Planned) |
Elayaraja Kolanthai |
| Abstract Scope |
Silk exhibits remarkable biocompatibility and biodegradability, making it an ideal material particularly for wound healing applications. However, pathological wound environments often exhibit have high concentrations of reactive oxygen species (ROS) generated by affected cells and microbial infections. The address this issue, we developed cerium oxide (CNPs), Ag-CNPs and nanocomposites of CNPs/silk and AgCNPs/silk using wet chemical and electrospinning techniques. The CNPs possess a mixed Ce3+/Ce4+ valence and exhibit enzyme mimetic activity by capturing and releasing oxygen from their surfaces. This unique property enables them to modulate ROS concentrations in cellular environments, making them effective therapeutic agents. Similarly, the silk/AgCNPs nanocomposites release Ag+ ions, which exhibit a broad-spectrum antimicrobial effect by disrupting microorganism biofilms in the wound area. Various techniques were employed to identify the functional groups, morphology, and structural as well as antimicrobial activity of the scaffolds. The developed nanocomopsoites could be a alternative materials for wound dressing materials. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Composites |