| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
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| Symposium
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Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
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| Presentation Title |
Effects of Zinc Deficiency and Arsenic Co-Exposure on Bone in Growing Female Mice |
| Author(s) |
Russell T Turner, Laura M Beaver, Carmen P Wong, Laurie G Hudson, Emily P Ho, Adam J Branscum, Urszula T. Iwaniec |
| On-Site Speaker (Planned) |
Russell T Turner |
| Abstract Scope |
Arsenic contamination in groundwater often co-exists with Zinc (Zn) deficiency. This study evaluated the effect of Zn deficiency (severe and moderate) and arsenic co-exposure on bone mass and cortical and cancellous bone microarchitecture in growing mice. 3-4-week-old female C57BL/6 mice were randomized to severe Zn-deficient (< 0.5 mg Zn/kg diet), marginal Zn-deficient (6 mg Zn/kg diet), or Zn-adequate (30 mg Zn/kg diet) diets. Mice were given 0, 50 or 500 ppb sodium arsenite in drinking water for 4-6 weeks (n=8/treatment group). Femurs were evaluated using dual energy x-ray absorptiometry and microcomputed tomography. Severe but not marginal Zn deficiency lowered bone mass and density and altered cortical and cancellous bone microarchitecture (lower midshaft cortical thickness and lower cancellous bone volume fraction). Sodium arsenite co-exposure had little effect on bone in either severely Zn-deficient or marginally Zn-deficient mice, suggesting co-exposure does not alter skeletal response to severe Zn deficiency during growth. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Other, |