| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Bone Growth at Breast Cancer Metastasis Evaluated using an In-vitro Cancer Metastasis Model |
| Author(s) |
Kalpana S. Katti, Sumanta Kar, Haneesh Jasuja, Dinesh R Katti |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
Breast cancer deaths are often associated with skeletal complications from metastasis to bone. Tumor growth at metastasis is ill understood and treatments often include bone stabilization. We have developed a novel in vitro model of breast cancer bone metastasis using nanoclay scaffolds seeded with human mesenchymal stem cells (MSCs) and human breast cancer cells (MCF-7 and MDA MB 231). Investigation of bone structures at tumor sites indicate highly disturbed morphology of the mineralized collagen. Since the Wnt/β-catenin signaling pathway plays a crucial role in the bone regenerative process, we specifically evaluate this pathway at breast cancer bone metastasis. We report that Wnt/ β-catenin signaling pathway has a significant effect on osteogenesis during breast cancer bone metastasis with MCF-7 and MDA MB 231. Our studies indicate that Wnt/β-catenin signaling governs osteogenesis within the metastasized bone environment. The nanoclay scaffold provides a useful testbed approach for investigating pathways of cancer metastasis. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |