| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Synthetic Salmon Calcitonin Alters the Mineral: Matrix Nanostructure of Mice with Chronic Kidney Disease |
| Author(s) |
Elizabeth Montagnino, William Bush, Thomas Siegmund, John Howarter, Rachel Surowiec |
| On-Site Speaker (Planned) |
Elizabeth Montagnino |
| Abstract Scope |
Chronic Kidney Disease (CKD) causes disruption to the mineral homeostasis leading to mineral and bone disorder. The onset of CKD causes the bone to become fragile and porous. Calcitonin, a hormone, secreted by the parathyroid hormone, helps regulate the calcium in the blood stream. We hypothesize that calcitonin treatment reduces alters bone nanostructure. We consider four groups of fifteen-week-old male C57BL/6J mice, wildtype samples with/without synthetic salmon calcitonin treatment and CKD samples with/without calcitonin intervention. Small and wide angle x-ray scattering analysis was performed to understand the nanoscale mineral-matrix structure with CKD and the effects of calcitonin treatment. Samples with CKD possessed smaller mineral particles, with higher order of clustering, and calcitonin shows possible signs of bone turnover via lower particle clustering and larger mineral particles. This work is supported by NSF Award 1952993 |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, |