| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Tissue-adhesive Hydrogel for Multimodal Drug Release to Immune Cells in Skin |
| Author(s) |
Nicole Day, Rianne Dalhuisen, Nichole Loomis, Sarah Adzema, C.Wyatt Shields IV, Jai Prakash |
| On-Site Speaker (Planned) |
Nicole Day |
| Abstract Scope |
There is a need for transdermal drug delivery systems that can target both innate and adaptive immune cells for the treatment of skin disease at independently tunable rates. We describe a tissue-adhesive hydrogel system that contains silicone particles capable of regulating the release of drugs, resiquimod (macrophage-stimulating) and palbociclib (T cell-stimulating). These small molecules are encapsulated within two types of particles embedded within the hydrogel. We demonstrate that drug release is mediated by particle crosslink density, allowing bulk properties of the hydrogel to be decoupled from drug release kinetics. We show that this hydrogel can be used to sustainably polarize macrophages toward an anti-tumor phenotype both in vitro and ex vivo, and that the hydrogels can remain stably attached to skin explants for several days. The multimodal, tunable nature of this hydrogel system has implications in treating a variety of skin disorders, managing infections, and delivering vaccines at well-defined rates. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Other, |