| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
Effects of Corona Treatment on Cellular Attachment and Morphology on Polydimethylsiloxane Micropillar Substrates |
| Author(s) |
Md Shahriar, Eduardo Pena, Jiachen Liu, Zhengyi Zhang, Changxue Xu |
| On-Site Speaker (Planned) |
Md Shahriar |
| Abstract Scope |
PDMS, a silicon-based elastomer is a widely used material in biomedical and microfluidic research. However, the intrinsic hydrophobic nature of PDMS hinders cellular attachment on the PDMS substrates. Corona discharge is widely used as a facile and robust method of surface treatment of PDMS substrates. This study investigates the effects of corona discharge on cellular attachment and morphology. With the increase of corona discharge time, the hydrophobic methyl groups are converted into polar silanol groups which significantly improves surface wettability and surface energy, as well as the corresponding cellular attachment and aspect ratio. However, prolonged corona discharge deteriorates surface wettability and cellular attachment due to crack formation. Higher water contact angle and reduced cell attachment are observed on thinner (0.1 mm) and thicker (1.5mm) samples. The optimal conditions observed are 0.5 mm sample thickness and corona discharge time of 60 seconds showing the best cellular attachment and morphology. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |