| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Micro- and Nanomechanics of Collagen-rich Tissues and Individual Fibrils |
| Author(s) |
Philipp Thurner, Mathis Nalbach, Magdalena Fuchs, Orestis Andriotis, Alessandra Carriero, Georg Schitter |
| On-Site Speaker (Planned) |
Philipp Thurner |
| Abstract Scope |
Collagens make up about 30% of the protein mass in the human body. The collagen family of proteins provides passive mechanical function to tissues and organs and acts as a scaffold for cells providing feedback for mechanosensory cells. Therefore the micro- and nanoscale of tissues comprising, collagen fibrils, are of great interest but remain understudied. Collagens provide a wide range of properties depending on tissue type and these properties are subject to change due to age and pathology. For this purpose we have conducted a number of studies in recent years both considering the micro- and nanoscale mechanical properties. In this context we have also developed a nanomechanical testing device that allows characterization of individual fibrils with rapid coupling and uncoupling and true force and distance control. This talk will give insight on the influence of several parameters including enzymatic and non-enzymatic cross-linking, hydration as well as structural mutation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Mechanical Properties |