| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
H-15: The Nanoscale Interface and Structure Function Properties of Cortical Bone |
| Author(s) |
Elizabeth Montagnino, William Bush , Thomas Siegmund , John Howarter |
| On-Site Speaker (Planned) |
Elizabeth Montagnino |
| Abstract Scope |
At the nanoscale of bone, exists the hard and soft material interface between type-I collagen (organic) and carbonated apatite (inorganic). Collagen’s elasticity and the strength from the mineral allows for bone to be a high load bearing structure which withstands everyday physiological strain. Although when bone becomes aged or diseased, there is stunted proficiency in bone’s remodeling cycle and ultimately causes decreased fracture toughness. To prevent bone fragility, and bypass dependence on osteological function, the junction of the nanoscale phases can be manipulated to further engineer favorable structure-function properties. In this study pharmaceutical intervention and bound water manipulation at the nanoscale interface was studied via wide angle x-ray scattering with in-situ tensile testing and Raman spectroscopy to show the resulting structure-property shifts and how they relate to fracture toughness in fragile bone. This work is supported by NSF Award 1952993. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Thin Films and Interfaces, |