| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
The Osteoinductive Capacity of Demineralized Allogenic Bone Matrix Is Impaired
By Chronic Heavy Alcohol Consumption
|
| Author(s) |
Urszula T. Iwaniec, Adam J Branscum, Russell T Turner |
| On-Site Speaker (Planned) |
Urszula T. Iwaniec |
| Abstract Scope |
Allografts play an important role in treatment of bone fractures or deformities. The purpose of this investigation was to test the hypothesis that alcohol consumption impairs graft incorporation by lowering osteoinductive capacity. We performed experiments using a demineralized allogeneic bone matrix (DABM) model in which DABM harvested from donor rats fed control or ethanol diet is implanted subcutaneously into recipient rats fed control or ethanol diet. Bone formed during osteoinduction was measured by micro-computed tomography. Experiment 1: Bone volume was lower in DABM recovered 6 weeks following implantation into rats fed control diet, indicating that exposure of the donor rats to ethanol lowered osteoinductive capacity. Experiment 2: Bone volume was greatest in DABM from control donors implanted into control recipients, intermediate in DABM from control donors implanted into ethanol-consuming recipients, and lowest in DABM from ethanol-consuming donors implanted into ethanol-consuming recipients. Our results suggest that alcohol impairs osteoinduction in allographs. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, |