| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
Biomimetic Collagen-Based 3D Printed Poly (Glycerol Sebacate) Composite Scaffold to Enhance Cartilage Defect Repair |
| Author(s) |
Yuyao Liu, Claudio Intini, Marko Dobricic, Fergal J. O'brien, Mónica Echeverry-Rendón, Javier Llorca |
| On-Site Speaker (Planned) |
Javier Llorca |
| Abstract Scope |
In this study, a noveel composite scaffold with hierarchical porosity consisted of a porous 3D printed poly (glycerol sebacate) (PGS) scaffold and a highly porous prochondrogenic collagen type I/II - hyaluronic acid (CI/II-HyA) matrix was designed. The composite scaffold exhibited mechanical properties, similar to the joint tissue. The incorporation of the CI/II-HyA matrix increased cell loading efficiency and improved the overall cell viability of rat-derived MSCs. Additionally, the combination of CI/II-HyA matrix and PGS scaffold sustained an effective and high-quality rat-derived MSC chondrogenic differentiation with an abundant de-novo cartilage-like matrix deposition by day 28. Overall, the biomimetic composite scaffold has the ability to support cartilage tissue growth and stimulate MSC cell proliferation and chondrogenic differentiation, showing significant potential in en-hancing cartilage defect repair. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Polymers, Biomaterials, |