| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
The Development of Antimicrobial Ti-Cu Alloys and Understanding of their Mode of Action |
| Author(s) |
Daisy Rabbitt, Luke N Carter, Victor Villapun, Sophie Cox, Alexander Knowles |
| On-Site Speaker (Planned) |
Daisy Rabbitt |
| Abstract Scope |
Innovation of metallic materials for biomedical implants is stagnant in comparison to other industries, with titanium alloys being dominant, due to excellent mechanical properties and biocompatibility. Nevertheless, there are a number of unaddressed challenges facing orthopaedic implants, in particular infection. Colonisation of device surfaces with bacteria may lead to implant revision or severe consequences to the patient’s quality of life.
Herein we aim to design an inherently antimicrobial alloy that prevents or limits bacterial growth and colonisation. Titanium-copper alloys have been researched as a method to kill bacteria; however, the mechanism of action has still been widely debated. Consequently, different Ti-Cu compositions have been evaluated. Varying manufacturing methods and heat treatments have been used to produce different microstructures and phases to fully explore these compositions. Characterisation techniques have been used to determine how the composition, phases, and microstructure all work together to help establish their efficacy and mode of action. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Titanium, Copper / Nickel / Cobalt |