| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Mechanical Properties of Tough, Mechanochemically Active Hydrogels |
| Author(s) |
Jamie J. Kruzic, Yuwan Haung, Bhakthi Jayathilaka, Kristopher A. Kilian |
| On-Site Speaker (Planned) |
Jamie J. Kruzic |
| Abstract Scope |
Inspired by how forces in biological tissues guide matrix deposition, we have developed bioinspired chemistry where an applied force facilitates molecule immobilization through distinct chemical handles built into a synthetic hydrogel network. As a proof of principle, this concept has been demonstrated using poly(ethylene glycol) (PEG) hydrogels that are formed through model force-responsive disulphide linkages where bond scission is able to catalyze reactions with complementary groups (e.g., acryloyl and/or maleimide). Furthermore, recognizing that single network hydrogels suffer from inherent brittleness that make them poor choices for load bearing bioengineering applications, we have incorporated these mechanochemically active networks into tough, double network hydrogels reinforced with alginate to mimic the interpenetrating networks of biomolecules found in living tissue. This presentation will report on the mechanical and functional properties of these double network, mechanochemically active hydrogels. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |