| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Mechanically and Biologically Tunable Biomaterials |
| Author(s) |
Dinesh Katti, Krishna Kundu, Hanmant Gaikwad, Sharad Jaswandkar, Pooyan Vahidi Pashaki, Kalpana Katti |
| On-Site Speaker (Planned) |
Dinesh Katti |
| Abstract Scope |
Tissue engineering scaffolds for bone tissue regeneration and 3D bone metastases with tunable mechanical properties and biological responses would overcome many challenges in biomaterials. Three unnatural amino acids were used to modify the montmorillonite clay to synthesize polymer clay nanocomposites (PCN) to make 3D bone-mimetic scaffolds. Molecular dynamics simulations drove the choice of amino acids. Although a tiny proportion of the scaffold, the presence and type of amino acid significantly affected the mechanical properties. The different amino acids in the nanoclays also influenced the amount of mineralization on the human mesenchymal stem cells seeded scaffolds. The osteoblastic nature of cancer cells on the regenerating bone scaffold enhanced mineralization and was influenced by the type of amino acid. This work demonstrates the ability to tune the mechanical and biological properties by different amino acid modifications in PCN-based biomaterials driven by simulations. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Computational Materials Science & Engineering |