| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
|
| Presentation Title |
Bone Formation via Acoustic Radiation Force: Transdermal Stimulation of Hydrogel-encapsulated Stem Cells |
| Author(s) |
Yusuf Khan, Kevin Grassie, Hanna Anderson, William Linthicum, Bryan Huey, Fayekah Assanah |
| On-Site Speaker (Planned) |
Yusuf Khan |
| Abstract Scope |
Tissue Engineering continues to be a viable strategy for healing large scale, complex injuries to both hard and soft tissue, with many approaches being added to the clinical armamentarium. Here we sought to combine both clinical and preclinical strategies into a solution for healing bony defects by combining hydrogel-based cell delivery with low intensity pulsed ultrasound, a clinically proven treatment for fractures, to permit the implantation of cell-laden hydrogels into large-scale bone defects followed by intermittent transdermal application of LIPUS-derived acoustic radiation force to the implanted cells. We have also developed in silico models that predict the mechanical forces applied to encapsulated cells and can serve as a design guide for our system. In vivo evaluation of our system has demonstrated full defect healing in large scale bone defects, suggesting that this system may be used for bony repair and with further refinement may have clinical utility. |