| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
|
| Presentation Title |
Mechanical Investigation of a Tandem Embolization-visualization System for Minimally Invasive Procedures |
| Author(s) |
Peng Chen, Jingjie Hu |
| On-Site Speaker (Planned) |
Peng Chen |
| Abstract Scope |
Transcatheter arterial embolization as a minimally invasive procedure has been extensively applied for treatment of tumors. Alginate microspheres have been utilized as embolic material for their low cost, biocompatibility, and controllable sizes. Using a facile one-step gas blowing technique, we engineered indocyanine green (ICG) loaded alginate microspheres for fluorescence image-guided procedure. Rheology was conducted for ICG-microspheres, showing no significant change in storage modulus of microspheres with different ICG content (up to 1 mg/mL). In addition, ICG-microspheres with increasing cross-linking degree were successfully synthesized, showing enhanced Young’s modulus as confirmed by parallel plate compression testing. The ICG-microspheres showed stability over months. These results suggested the feasibility to tune the mechanical property of ICG-microspheres with the same sizes. Hemocompatibility, cell viability assay and NIR imaging were conducted to further explore the potential of ICG-microspheres as real-time tracking embolic agent for tumor resection. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Mechanical Properties, Biomaterials, Polymers |